| Recently, a patient sent me a message telling me that they are just “wired to be an anxious person.” I was a bit shocked at their comment and realized that this person completely misunderstood and misinterpreted a recent study describing the “worrier gene.” The “worrier gene” concept stems from research like the Journal of Sports Science and Medicine study (2025), which found that elite mixed martial arts athletes are more likely to have the warrior (Val158) genotype, while worrier (Met158) carriers showed higher anxiety but better cognitive performance. These are variants of the SNPs (single nucleotide polymorphisms) of the COMT gene. The idea of a “worrier gene” often refers to a variation or SNP in the COMT gene (Catechol-O-Methyltransferase), leading to more slow break down of how the brain processes dopamine, a neurotransmitter linked to mood and stress responses. Additionally, some individuals with the worrier genotype may struggle initially with stress but can build resilience through consistent exposure, unlike the warrior genotype, which handles stress more readily but may underperform in memory tasks. Specifically, the Val158Met polymorphism or SNP in the COMT gene has been studied for its association with anxiety and stress sensitivity. Met allele or SNP carriers tend to have lower COMT enzyme activity, leading to higher dopamine levels in the prefrontal cortex. This is sometimes linked to heightened emotional reactivity and anxiety, earning it the nickname “worrier gene.” It even has been associated with a lower pain threshold and increased susceptibility to psychological stress, which may influence conditions like fibromyalgia, anxiety disorders, and even post-burn outcomes such as scarring and pruritus (itching). Val allele or SNP carriers have higher COMT activity, breaking down dopamine faster, which may be associated with a “warrior” trait—better stress resilience but potentially less emotional sensitivity. Studies, like those published in journals such as Neuroscience Letters (2017), show mixed results. The Met allele may increase anxiety in certain contexts, especially under stress, However, environmental factors (e.g., upbringing, life experiences) play a massive role in our coping mechanisms. No single gene determines if you’re a “worrier”—it’s a very complex interplay of genetics AND environment. We do know that activities like martial arts, horseback riding, yoga, and nutritional support can powerfully mitigate stress effects. Leafy green herbs can also mitigate dopamine levels in worriers. These include green tea (in the herbal form not the tea) Valerian root, and some berries. Products that I have found to contain the natural herbal remidies to these SNPs and to be very helpful are V-Italay and Glutitation. |
| To Your Health & Longevity, Adam Nally, DO |
The Doc, The Horse & The Sword 